Search results for "Microcirculatory Bed"

Evaluation of Oxygen Diffusion Distances in Human Breast Cancer Using Cell Line Specific in Vivo Data: Role of Various Pathogenetic Mechanisms in the…

1988

Radiobiological hypoxia in malignant tumors has been shown to originate (i) from spatial and temporal functional disturbances of tumor microcirculation resulting in a limited convective O2 flux in microregions even in tissue areas exhibiting high vascular densities, and (ii) from morphological abnormalities of the microcirculatory bed leading to a limitation of the diffusive O2 flux. In addition to these pathogenetic mechanisms, systemic factors (anemia, arterial hypoxia) can also play a role in the development of tumor hypoxia.